Associazione tra esposizione a malaria e l'herpes virus che causa il sarcoma di Kaposi


Association between malaria exposure and Kaposi's sarcoma associated herpes virus seropositivity in Uganda.

Trop Med Int Health. 2015 Jan 22.


Nalwoga A1, Cose S, Wakeham K, Miley W, Ndibazza J, Drakeley C, Elliott A, Whitby D, Newton R.

Medical Research Council /Uganda Virus Research Institute, Entebbe, Uganda.

Abstract
OBJECTIVE:

Unlike other herpes viruses, Kaposi's sarcoma-associated herpes virus (KSHV) is not ubiquitous worldwide and is most prevalent in sub-Saharan Africa. The reasons for this are unclear. As part of a wider investigation of factors that facilitate transmission in Uganda, a high prevalence country, we examined the association between anti-malaria antibodies and seropositivity against KSHV.
METHODS:

Antibodies against P. falciparum Merozoite Surface Protein (PfMSP)-1, P. falciparum Apical Membrane Antigen (PfAMA)-1 and KSHV antigens (ORF73 and K8.1) were measured in samples from 1164 mothers and 1227 children.
RESULTS:

KSHV seroprevalence was 69% among mothers and 15% children. Among mothers, KSHV seroprevalence increased with malaria antibody titres: from 60% to 82%, and from 54% to 77%, comparing those with the lowest and highest titres for PfMSP-1 and PfAMA-1, respectively (P<0.0001). Among children, only antibodies to PfAMA-1 were significantly associated with KSHV seropositivity, (p<0.0001). In both mothers and children, anti-ORF73 antibodies were more strongly associated with malaria antibodies than anti-K8.1 antibodies.
CONCLUSION:

The association between malaria exposure and KSHV seropositivity suggests that malaria is a cofactor for KSHV infection or reactivation. This article is protected by copyright. All rights reserved.

 

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